Description
Encorafenib (LGX818) is a potent mutated BRafV600E inhibitor (IC₅₀ = 0.3 nM) with potential antineoplastic activity. Displays little activity against wild-type B-Raf or a panel of 100 other kinases (IC₅₀s = 900 nM).
Encorafenib (LGX818) is a potent mutated BRafV600E inhibitor (IC₅₀ = 0.3 nM) with potential antineoplastic activity. Displays little activity against wild-type B-Raf or a panel of 100 other kinases (IC₅₀s = 900 nM).
Alternate Name/Synonyms: (S)-methyl (1-((4-(3-(5-chloro-2-fluoro-3-(methylsulfonamido)phenyl)-1-isopropyl-1H-pyrazol-4-yl)pyrimidin-2-yl)amino)propan-2-yl)carbamate; LGX818
Appearance: White to off-white solid
Formulation: N/A
CAS Number: 1269440-17-6
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₂H₂₇ClFN₇O₄S
Molecular Weight: 540.01
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A potent mutated BRafV600E inhibitor
MDL Number: N/A
PubChem CID: 50922675
SMILES: CC(C)N1C=C(C(=N1)C2=CC(=CC(=C2F)NS(=O)(=O)C)Cl)C3=NC(=NC=C3)NCC(C)NC(=O)OC
InChi: InChI=1S/C22H27ClFN7O4S/c1-12(2)31-11-16(17-6-7-25-21(28-17)26-10-13(3)27-22(32)35-4)20(29-31)15-8-14(23)9-18(19(15)24)30-36(5,33)34/h6-9,11-13,30H,10H2,1-5H3,(H,27,32)(H,25,26,28)/t13-/m0/s1
InChi Key: CMJCXYNUCSMDBY-ZDUSSCGKSA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |