Endonuclease G polyclonal Antibody | CAS75127

Endonuclease G polyclonal Antibody | CAS75127 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Rat,Mouse

Application: WB IP IHC

Application Range: WB: 1:2000~1:5000 IP:1:2000~8000 IHC:1:50~1:100

Background: Endonuclease G (EndoG) is a nuclear-encoded mitochondrial nuclease that has been reported to function in apoptosis, DNA recombination and cell proliferation. EndoG is expressed as a precursor protein containing an amino-terminal mitochondrial targeting sequence which is removed when the protein is imported into the mitochondria. During apoptosis EndoG is released from the mitochondria, translocates to the nucleus and cooperates with other nucleases to trigger DNA fragmentation associated with the apoptotic process

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: Endonuclease G polyclonal Antibody detects endogenous levels of Endonuclease G protein.

Molecular Weight: ~ 30 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Endonuclease G, mitochondrial ; Endo G; ENDOG

Immunogen: Recombinant protein of human Endonuclease G.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: Mitochondrial Control of Apoptosis,Death Receptor Signaling,