Endostatin, human recombinant | 4759

Endostatin has been identified as a C-terminal fragment of Collagen type 18, a recently identified member of a family of collagen-like proteins referred to as multiplexin family Endostatin specifically inhibits proliferation of endothelial cells although it does not affect the proliferation of EOMA cells. Endostatin also potently inhibits angiogenesis and tumor growth. Endostatin has an important role in endothelial cell adhesion and cytoskeletal organization. Endostatin can be found in vessel walls (elastic fibers) and basement membranes. Recombinant human Endosatin expressed in yeast causes G1 arrest of endothelial cells, and endostatin treatment results in apoptosis of HUVE and HMVE cells.

4759 | Endostatin human recombinant DataSheet

Biomolecule/Target: N/A

Synonyms: Collagen alpha-1(XVIII) chain

Alternates names: soluble IL-6 receptor alpha, B cell stimulatory factor-2, CD126

Taglines: An anti-angiogenic agent

NCBI Gene ID #: 3570

NCBI Gene Symbol: IL6R

Gene Source: Human

Accession #: P08887

Recombinant: Yes

Source: E. coli

Purity by SDS-PAGEs: 98%

Assay: SDS-PAGE

Purity: N/A

Assay #2: HPLC

Endotoxin Level: <0.1 ng/g

Activity (Specifications/test method): N/A

Biological activity: The ED50 as determined by its ability to intensify the IL-6 induced growth inhibition of murine M1 cells is <5.0 ng/ml, in the presence of 20 ng/ml of rhIL-6.

Results: N/A

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: 37.6 kDa

Concentration: N/A

Appearance: Lyophilized protein

Physical form description: Sterile filtered and lyophilized from 50 mM Tris, pH 8.0

Reconstitution Instructions: Centrifuge the vial prior to opening. Reconstitute in PBS, pH 7.4. Do not vortex.

Amino acid sequence: N/A