26
Endostatin, human recombinant | 4759
- SKU:
- 26-4759-GEN
- Availability:
- Usually shipped in 5 working days
Description
Endostatin has been identified as a C-terminal fragment of Collagen type 18, a recently identified member of a family of collagen-like proteins referred to as multiplexin family Endostatin specifically inhibits proliferation of endothelial cells although it does not affect the proliferation of EOMA cells. Endostatin also potently inhibits angiogenesis and tumor growth. Endostatin has an important role in endothelial cell adhesion and cytoskeletal organization. Endostatin can be found in vessel walls (elastic fibers) and basement membranes. Recombinant human Endosatin expressed in yeast causes G1 arrest of endothelial cells, and endostatin treatment results in apoptosis of HUVE and HMVE cells.
4759 | Endostatin human recombinant DataSheet
Biomolecule/Target: N/A
Synonyms: Collagen alpha-1(XVIII) chain
Alternates names: soluble IL-6 receptor alpha, B cell stimulatory factor-2, CD126
Taglines: An anti-angiogenic agent
NCBI Gene ID #: 3570
NCBI Gene Symbol: IL6R
Gene Source: Human
Accession #: P08887
Recombinant: Yes
Source: E. coli
Purity by SDS-PAGEs: 98%
Assay: SDS-PAGE
Purity: N/A
Assay #2: HPLC
Endotoxin Level: <0.1 ng/g
Activity (Specifications/test method): N/A
Biological activity: The ED50 as determined by its ability to intensify the IL-6 induced growth inhibition of murine M1 cells is <5.0 ng/ml, in the presence of 20 ng/ml of rhIL-6.
Results: N/A
Binding Capacity: N/A
Unit Definition: N/A
Molecular Weight: 37.6 kDa
Concentration: N/A
Appearance: Lyophilized protein
Physical form description: Sterile filtered and lyophilized from 50 mM Tris, pH 8.0
Reconstitution Instructions: Centrifuge the vial prior to opening. Reconstitute in PBS, pH 7.4. Do not vortex.
Amino acid sequence: N/A