ENPP3 Antibody (C-term) [APR07716G]

ENPP3 Antibody (C-term) [APR07716G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This ENPP3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 814-843 amino acids from the C-terminal region of human ENPP3.

Cellular Localisation: Cell membrane; Single-pass type II membrane protein. Apical cell membrane; Single-pass type II membrane protein. Secreted Note=Detected at the cell surface of basophils (PubMed:11342463) Detected at the apical plasma membrane of bile duct cells (PubMed:15072822) . Located to the apical surface in intestinal and kidney epithelial cells. Secreted in serum, and in lumen of epithelial cells.

Molecular Weight: 100124

Clone: Polyclonal

Gene Name: ENPP3

Gene ID: 5169

Function: Hydrolase that metabolizes extracellular nucleotides, including ATP, GTP, UTP and CTP (PubMed:29717535) . Limits mast cell and basophil responses during inflammation and during the chronic phases of allergic responses by eliminating the extracellular ATP that functions as signaling molecule and activates basophils and mast cells and induces the release of inflammatory cytokines. Metabolizes extracellular ATP in the lumen of the small intestine, and thereby prevents ATP-induced apoptosis of intestinal plasmacytoid dendritic cells (By similarity) . Has also alkaline phosphodiesterase activity (PubMed:11342463) .

Summary: Tissue Location: Detected on bile ducts in liver, and in blood serum (at protein level) (PubMed:15072822) . Detected in prostate and uterus (PubMed:9344668) . Detected on basophils, but not neutrophils (PubMed:11342463) .

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: Ectonucleotide pyrophosphatase/phosphodiesterase family member 3, E-NPP 3, Phosphodiesterase I beta, PD-Ibeta, Phosphodiesterase I/nucleotide pyrophosphatase 3, CD203c, Alkaline phosphodiesterase I, Nucleotide pyrophosphatase, NPPase, ENPP3, PDNP3