EPM2A Antibody | 7023

EPM2A Antibody | 7023 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse, Rat

Homology: N/A

Immunogen: EPM2A antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of human EPM2A.
The immunogen is located within amino acids 190 - 240 of EPM2A.

Research Area: Neuroscience

Tested Application: E, WB, ICC, IF

Application: EPM2A antibody can be used for detection of EPM2A by Western blot at 1 - 2 μg/mL.
Antibody validated: Western Blot in human samples; Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Specificiy: At least four isoforms of EPM2A are known to exist; this antibody will detect all but the shortest isoform.

Positive Control 1: Cat. No. 1221 - SW480 Cell Lysate

Positive Control 2: N/A

Positive Control 3: N/A

Positive Control 4: N/A

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: 36 kDa

Validation: N/A

Isoform: N/A

Purification: EPM2A Antibody is affinity chromatography purified via peptide column.

Clonality: Polyclonal

Clone: N/A

Isotype: IgG

Conjugate: Unconjugated

Physical State: Liquid

Buffer: EPM2A Antibody is supplied in PBS containing 0.02% sodium azide.

Concentration: 1 mg/mL

Storage Condition: EPM2A antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Alternate Name: EPM2A Antibody: EPM2, MELF, Laforin, Lafora PTPase, LAFPTPase

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: EPM2A Antibody: The Epilepsy, progressive myoclonus type 2A protein (EPM2A) is a dual-specificity phosphatase that associates with polyribosomes. Mutations in this gene have been associated with myoclonic epilepsy of Lafora. EPM2A interacts with a number of proteins known to be involved in glycogen metabolism and has been shown to have robust phosphatase activity against a phosphorylated complex carbohydrate, suggesting that EPM2A may be involved in the regulation of glycogen metabolism.