EPOR Antibody (Center) [APR04127G]

EPOR Antibody (Center) [APR04127G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This EPOR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 329-357 amino acids from the Central region of human EPOR.

Cellular Localisation: Cell membrane; Single-pass type I membrane protein

Molecular Weight: 55065

Clone: Polyclonal

Gene Name: EPOR

Gene ID: 2057

Function: Receptor for erythropoietin. Mediates erythropoietin-induced erythroblast proliferation and differentiation. Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STAT5 signaling cascade. In some cell types, can also activate STAT1 and STAT3. May also activate the LYN tyrosine kinase.

Summary: Tissue Location: Erythroid cells and erythroid progenitor cells. Isoform EPOR-F is the most abundant form in EPO-dependent erythroleukemia cells and in late-stage erythroid progenitors. Isoform EPOR-S and isoform EPOR-T are the predominant forms in bone marrow Isoform EPOR-T is the most abundant from in early-stage erythroid progenitor cells

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB, FC, IF

Dilution: WB--1:1000 FC--1:10~50 IF--1:10~50

Synonyms: Erythropoietin receptor, EPO-R, EPOR