Description
S-equol is a metabolite of soy isoflavonoid phytoestrogen daidzein, produced by human intestinal bacteria. S-equol has a high affinity for estrogen receptor beta (ERβ) than estrogen receptor (ERα) with Ki values of 0.73 and 6.4 nM respectively. It inhibits the growth of LnCaP, DU145 and PC3 human prostate cancer cell lines. It has significant anti-prostate cancer activities in vitro and in vivo. The anticancer effects are associated with the activation of FOXO3a via an Akt-specific pathway and inhibitory effects on MDM2 expression.
S-equol is a metabolite of soy isoflavonoid phytoestrogen daidzein, produced by human intestinal bacteria. S-equol has a high affinity for estrogen receptor beta (ERβ) than estrogen receptor (ERα) with Ki values of 0.73 and 6.4 nM respectively. It inhibits the growth of LnCaP, DU145 and PC3 human prostate cancer cell lines. It has significant anti-prostate cancer activities in vitro and in vivo. The anticancer effects are associated with the activation of FOXO3a via an Akt-specific pathway and inhibitory effects on MDM2 expression.
Alternate Name/Synonyms: (3S)-3-(4-hydroxyphenyl)-3,4-dihydro-2H-chromen-7-ol; (S)-Equol; 4',7-Isoflavandiol; 4',7-Dihydroxyisoflavan; (S)-3,4-Dihydro-3-(4-hydroxyphenyl)-2H-1-benzopyran-7-ol
Appearance: White Solid
Formulation:
CAS Number: 531-95-3
Structure Available?: TRUE
Peptide sequence:
Salt Form: FALSE
Molecular Formula: C₁₅H₁₄O₃
Molecular Weight: 242.27
Cell-Permeable?: TRUE
Purity: ≥ 98%
Solubilities: ~15 mg/ml in DMSO, DMF or ethanol
Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Country of Origin: USA
Tag Line: A high affinity agonist for ERβ
MDL Number: MFCD00200962
PubChem CID: 91469
SMILES: C1C(COC2=C1C=CC(=C2)O)C3=CC=C(C=C3)O
InChi: InChI=1S/C15H14O3/c16-13-4-1-10(2-5-13)12-7-11-3-6-14(17)8-15(11)18-9-12/h1-6,8,12,16-17H,7,9H2/t12-/m1/s1
InChi Key: ADFCQWZHKCXPAJ-GFCCVEGCSA-N
Additional Information
Storage Condition: |
-20ºC |
Shipping Condition: |
RT |
Shelf Life: |
36 months |