ERα (P124) polyclonal Antibody | BS5567

ERα (P124) polyclonal Antibody | BS5567 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: IHC

Application Range: IHC: 1:50~1:200

Background: The estrogen receptor-alpha (ER) is a broadly expressed transcription factor which controls a number of genes involved in cellular differentiation and proliferation. ER contains two transcriptionally active domains: the N-terminal domain (AF1) is constitutively active, while the C-terminal domain (AF-2) is hormone-dependent. ER is subject to post-translational modification, including phosphorylation of serine residues 104, 106, 118, and 167. This Antibody specifically recognizes human estrogen receptor-alpha when phosphorylated at serine 167, a site which influences AF-1 dependent transcriptional activity. This phosphorylation is catalyzed by the MAPK pathway, potentially through the 90 kDa ribosomal S6 kinase (pp90rsk1) . Serine 167 is also a consensus Akt substrate.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: ER-a (P124) polyclonal Antibody detects endogenous levels of ER-a protein.

Molecular Weight: ~ 66 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Estrogen receptor; ER-alpha; ER; ESR1; ESR; NR3A1

Immunogen: N/A

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: Notch Signaling,Nuclear Receptor Signaling,Cell Cycle Control G1 S Checkpoint,DNA Methylation,Epigenetic Writers and Erasers of Histone H3,Epigenetic Writers and Erasers of Histones H2A H2B and H4,