ERAF polyclonal Antibody | BS8238

ERAF polyclonal Antibody | BS8238 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB

Application Range: WB 1:500 - 1:2000

Background: α-hemoglobin stabilizing protein (AHSP), also designated erythroid associated factor (ERAF), is an erythroid-specific protein that acts as a chaperone to prevent the aggregation of α-hemoglobin during normal erythroid cell development.It specifically protects free α-hemoglobin from precipitation in live cells and in solution. It forms a heterodimer with free α-hemoglobin, but not with β-hemoglobin or hemoglobin A (α2-β-2) . AHSP localizes to the cytoplasm and is expressed in the blood and bone marrow. The AHSP protein is downregulated in transmissible spongiform encephalopathies (TSEs) . AHSP may regulate pathological states of α-hemoglobin excess such as β-thalassemia,a group of hereditary disorders involving the decreased production of normal adult hemoglobin (HbA) that are characterized by a deficiency in the synthesis of β-globin chains.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: ERAF polyclonal Antibody detects endogenous levels of ERAF protein.

Molecular Weight: ~ 12 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Alpha-hemoglobin-stabilizing protein; Erythroid differentiation-related factor; Erythroid-associated factor; AHSP; EDRF; ERAF

Immunogen: Recombinant full length Human ERAF.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: