ERO1LB Polyclonal Antibody | BS65778

ERO1LB Polyclonal Antibody | BS65778 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat,Rabbit,Guinea Pig,

Application: WB,

Application Range: WB=1:500-2000

Background: Essential oxidoreductase that oxidizes proteins in the endoplasmic reticulum to produce disulfide bonds. Acts by oxidizing directly P4HB/PDI isomerase through a direct disulfide exchange. Does not act as a direct oxidant of folding substrate, but relies on P4HB/PDI to transfer oxidizing equivalent. Associates with ERP44 but not with GRP54, demonstrating that it does not oxidize all PDI related proteins and can discriminate between PDI and related proteins. Its reoxidation probably involves electron transfer to molecular oxygen via FAD. Acts independently of glutathione. May be responsible for a significant proportion of reactive oxygen species (ROS) in the being a source of oxidative stress. Required for the folding of cell, thereby being a source of oxidative stress.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: ERO1LB Polyclonal Antibody detects endogenous levels of ERO1LB protein.

Molecular Weight: 50 kD

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Endoplasmic oxidoreductin-1-like protein B; ERO1-L-beta; ERO1B_HUMAN; ERO1-like protein beta; Oxidoreductin-1-L-beta.

Immunogen: KLH conjugated synthetic peptide derived from human ERO1LB:1-100/467

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: affinity purified by Protein A

Pathway: