ESCO1 Antibody (C-term) [APR32805G]

ESCO1 Antibody (C-term) [APR32805G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H, M

Specificity: This ESCO1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 661-687 amino acids from the C-terminal region of human ESCO1.

Cellular Localisation: Nucleus. Chromosome Note=Nuclear at interphase, associated with chromosomes during mitosis

Molecular Weight: 94983

Clone: Polyclonal

Gene Name: ESCO1

Gene ID: 114799

Function: Acetyltransferase required for the establishment of sister chromatid cohesion (PubMed:15958495, PubMed:18614053) . Couples the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together. In contrast to the structural cohesins, the deposition and establishment factors are required only during S phase. Acts by mediating the acetylation of cohesin component SMC3 (PubMed:18614053) .

Summary: Tissue Location: Widely expressed. Expressed in heart, brain, liver, placenta, lung, kidney and pancreas. Highly expressed in muscle

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: N-acetyltransferase ESCO1, 231-, CTF7 homolog 1, Establishment factor-like protein 1, EFO1p, hEFO1, Establishment of cohesion 1 homolog 1, ECO1 homolog 1, ESO1 homolog 1, ESCO1, EFO1, KIAA1911