ESPL1 Polyclonal Antibody | E-AB-13224

ESPL1 Polyclonal Antibody | E-AB-13224 | Gentaur UK, US & Europe Distribution

Type: Polyclonal Antibody

Synonyms: Caspase like protein ESPL1, Caspase-like protein ESPL1, ESP 1, ESP1, ESPL 1, Espl1, ESPL1, Extra spindle poles like 1, Extra spindle poles like 1 protein, Extra spindle poles-like 1 protein, FLJ46492, KIAA0165, Separase, Separin, Similar to fission yeast cut1and gene, SSE

Application: WB, IHC, ELISA

Reactivity: Human, Mouse

Host: Rabbit

Isotype: IgG

Reserch Areas: Cancer, Cell Biology, Epigenetics and Nuclear Signaling

Background: Stable cohesion between sister chromatids before anaphase and their timely separation during anaphase are critical for chromosome inheritance. In vertebrates, sister chromatid cohesion is released in 2 steps via distinct mechanisms. The first step involves phosphorylation of STAG1 or STAG2 in the cohesin complex. The second step involves cleavage of the cohesin subunit SCC1 by ESPL1, or separase, which initiates the final separation of sister chromatids.

Concentration: 0.5 mg/mL

Storage: Store at -20°C. Avoid freeze / thaw cycles.

Immunogen: Synthetic peptide of human ESPL1

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Purification Method: Affinity purification

Dilution: WB 1:200-1:1000, IHC 1:25-1:100

Clone: N/A

Conjugation: Unconjugated

Molecular Weight(Calculated): 233 kDa

Molecular Weight(Observed): N/A