Description
ESPL1 Polyclonal Antibody | E-AB-13224 | Gentaur UK, US & Europe Distribution
Type: Polyclonal Antibody
Synonyms: Caspase like protein ESPL1, Caspase-like protein ESPL1, ESP 1, ESP1, ESPL 1, Espl1, ESPL1, Extra spindle poles like 1, Extra spindle poles like 1 protein, Extra spindle poles-like 1 protein, FLJ46492, KIAA0165, Separase, Separin, Similar to fission yeast cut1and gene, SSE
Application: WB, IHC, ELISA
Reactivity: Human, Mouse
Host: Rabbit
Isotype: IgG
Reserch Areas: Cancer, Cell Biology, Epigenetics and Nuclear Signaling
Background: Stable cohesion between sister chromatids before anaphase and their timely separation during anaphase are critical for chromosome inheritance. In vertebrates, sister chromatid cohesion is released in 2 steps via distinct mechanisms. The first step involves phosphorylation of STAG1 or STAG2 in the cohesin complex. The second step involves cleavage of the cohesin subunit SCC1 by ESPL1, or separase, which initiates the final separation of sister chromatids.
Concentration: 0.5 mg/mL
Storage: Store at -20°C. Avoid freeze / thaw cycles.
Immunogen: Synthetic peptide of human ESPL1
Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Purification Method: Affinity purification
Dilution: WB 1:200-1:1000, IHC 1:25-1:100
Clone: N/A
Conjugation: Unconjugated
Molecular Weight(Calculated): 233 kDa
Molecular Weight(Observed): N/A