Estrogen Receptor Antibody (alpha)| F40335-0.08ML/R31605

Estrogen Receptor Antibody (alpha)| F40335-0.08ML/R31605 | Gentaur UK, US & Europe Distribution

Background: This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative splicing results in several transcript variants, which differ in their 5' UTRs and use different promoters.

Format: Purified

Clone: 415CT16.3.2.1

Host Animal: Mouse

Clonality: Monoclonal (mouse origin)

Isotype: Mouse IgG1

Species Reactivity: Human

Predicted Spacies Reactivity: Bovine, Mouse, Pig, Rat

Application: WB, ELISA

Application Details: Western blot: 1:100-1:250

Application Note: Titration of the Estrogen Receptor alpha antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Status: Available

Buffer: N/A

Limitation: This Estrogen Receptor alpha antibody is available for research use only.

Purity: Purified

Immunogen: A portion of amino acids 246-273 from the human protein was used as the immunogen for this Estrogen Receptor alpha antibody.

Storage: Aliquot the Estrogen Receptor alpha antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Localization: N/A