ET-BR polyclonal Antibody | BS90482

ET-BR polyclonal Antibody | BS90482 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Zebrafish

Application: WB IP

Application Range: WB:1:500-1:2,000 IP:1:10-1:50

Background: Endothelin receptor B (ETBR), also known as EDNRB, ETB, ETRB, HSCR and HSCR2, is a member of the guanine-binding, regulatory protein-coupled receptor family. Three isoforms of ETBR exist called isoform 1, isoform 2 and δ 3. ETBR is involved in the regulation of sodium excretion and glomular filtration rate (GFR) . ETBR plays a role in the normal development of the neural crestderived cell lineages, epidermal melanocytes and enteric neurons. ETBR is expressed in lung, kidney, placenta, skeletal muscle and stem villi vessels. Both of the ET receptors, ETAR and ETBR, are activated by ET1, which results in inhibition of active lens sodium-potassium transport. Activation of the ET receptors also causes an increase in cytoplasmic calcium concentration in cultured lens epithelial cells. ETBR deficiency causes early onset dysfunction of the kidney, characterized by reduced sodium excretion, decreased GFR and slightly elevated blood pressure. Mutations in the gene encoding ETBR produce congenital aganglionic megacolon and pigment abnormalities. The multigenic disorder, Hirschsprung’s disease type 2, is also due to a mutation in the ETBR gene.

Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: ET-BR polyclonal Antibody detects endogenous levels of ET-BR protein.

Molecular Weight: 50 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: ET-B, ET-BR, EDNRB, ABCDS, Ednra, EDNRB, EDNRB, Endothelin B receptor, Endothelin B receptor precursor, Endothelin receptor Non selective type, Endothelin receptor non-selective type, Endothelin receptor type B, ET B, ET-B, ET-BR, ETB, ETBR, ETRB, Hirschsprung disease 2, HSCR, HSCR2, OTTHUMP00000018534, OTTHUMP00000178736, WS4A,

Immunogen: recombinant protein

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: ProA affinity purified

Pathway: