BW
ETHE1 polyclonal Antibody | BS70132
- SKU:
- BW-BS70132
- Availability:
- Usually ships in 5 working days
Description
ETHE1 polyclonal Antibody | BS70132 | Gentaur UK, US & Europe Distribution
Host: Rabbit
Reactivity: Human,Mouse,Rat
Application: WB,IHC,IF
Application Range: WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
Background: ETHE1 (ethylmalonic encephalopathy 1), also known as HSCO (hepatoma subtracted clone one protein), is a 254 amino acid protein belonging to the metallo-beta-lactamase superfamily and glyoxalase II family. Localizing to the cytoplasm, nucleus and mitochondrion matrix, ETHE1 is ubiquitously expressed and may function in sulfide catabolism. ETHE1 binds two zinc ions per subunit and interacts directly with RELA, preventing its localization to the nucleus thus leading to suppressed p53-induced apoptosis. The gene encoding ETHE1 maps to human chromosome 19q13.31. Mutations to this gene result in ethylmalonic encephalopathy, an infantile metabolic disorder characterized by high levels of ethylmalonic acid, neurodevelopmental delay and regression, recurrent petechiae, acrocyanosis, and death within the first decade of life.
Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: ETHE1 polyclonal Antibody detects endogenous levels of ETHE1 protein.
Molecular Weight: ~ 28 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: HSCO; Sulfur dioxygenase ETHE1
Immunogen: Recombinant protein of human ETHE1.
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Pathway: