ETP-46464 | 2457

A potent ATR (ATM and Rad3-related) inhibitor (IC₅₀ = 25 nM). It also inhibits the activity of PI3Kα, mTOR and DNA-PKC with IC₅₀'s of 170, 0.6 and 36 nM, respectively. ETP-46464 inhibits the restart of stalled replication forks and abrogates S phase arrest after exposure to hydroxyurea.

ETP-46464 is a potent ATR (ATM and Rad3-related) inhibitor (IC₅₀ = 25 nM). It also inhibits the activity of PI3Kα, mTOR and DNA-PKC with IC₅₀'s of 170, 0.6 and 36 nM, respectively

2457 | ETP-46464 DataSheet

Alternate Name/Synonyms: 2-Methyl-2-(4-(2-oxo-9-(quinolin-3-yl)-2H-[1,3]oxazino[5,4-c]quinolin-1(4H)-yl)phenyl)propanenitrile; ATRi

Appearance: White solid

Formulation: N/A

CAS Number: 1345675-02-6

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₃₀H₂₂N₄O₂

Molecular Weight: 470.52

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (~10 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent ATR (ATM and Rad3-related) inhibitor

MDL Number: N/A

PubChem CID: N/A

SMILES: CC(C)(C#N)C(C=C1)=CC=C1N(C2=C(CO3)C=NC(C2=C4)=CC=C4C5=CC6=CC=CC=C6N=C5)C3=O

InChi: InChI=1S/C30H22N4O2/c1-30(2,18-31)23-8-10-24(11-9-23)34-28-22(17-36-29(34)35)16-33-27-12-7-19(14-25(27)28)21-13-20-5-3-4-6-26(20)32-15-21/h3-16H,17H2,1-2H3

InChi Key: DPLMXAYKJZOTKO-UHFFFAOYSA-N