Description
A potent and selective sphingosine-1-phosphate-1 (S1P1) receptor antagonist (IC₅₀ =1.88 nM in CHO cells).
Etrasimod (APD334) is a potent and selective sphingosine-1-phosphate-1 (S1P1) receptor antagonist (IC₅₀ =1.88 nM in CHO cells).
Alternate Name/Synonyms: APD-334,(3R)-7-[[4-cyclopentyl-3-(trifluoromethyl)phenyl]methoxy]-1,2,3,4-tetrahydro-cyclopent[b]indole-3-acetic acid,APD334
Appearance: Crystalline solid
Formulation:
CAS Number: 1206123-37-6
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: N/A
Molecular Formula: C₂₆H₂₆F₃NO₃
Molecular Weight: 457.49
Cell-Permeable?: Yes
Purity: ≥98%
Solubilities: >25 mg/ml (DMSO) in 0
Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Country of Origin: USA
Tag Line: A sphingosine-1-phosphate-1 (S1P1) receptor antagonist
MDL Number: N/A
PubChem CID: 44623998
SMILES: C1CCC(C1)C2=C(C=C(C=C2)COC3=CC4=C(C=C3)NC5=C4CCC5CC(=O)O)C(F)(F)F
InChi: InChI=1S/C26H26F3NO3/c27-26(28,29)22-11-15(5-8-19(22)16-3-1-2-4-16)14-33-18-7-10-23-21(13-18)20-9-6-17(12-24(31)32)25(20)30-23/h5,7-8,10-11,13,16-17,30H,1-4,6,9,12,14H2,(H,31,32)/t17-/m1/s1
InChi Key: MVGWUTBTXDYMND-QGZVFWFLSA-N
Additional Information
Storage Condition: |
-20ºC |
Shipping Condition: |
Gel Pack |
Shelf Life: |
12months |