Etrasimod | B2319

A potent and selective sphingosine-1-phosphate-1 (S1P1) receptor antagonist (IC₅₀ =1.88 nM in CHO cells).

Etrasimod (APD334) is a potent and selective sphingosine-1-phosphate-1 (S1P1) receptor antagonist (IC₅₀ =1.88 nM in CHO cells).

B2319 | Etrasimod DataSheet

Alternate Name/Synonyms: APD-334,(3R)-7-[[4-cyclopentyl-3-(trifluoromethyl)phenyl]methoxy]-1,2,3,4-tetrahydro-cyclopent[b]indole-3-acetic acid,APD334

Appearance: Crystalline solid

Formulation:

CAS Number: 1206123-37-6

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: N/A

Molecular Formula: C₂₆H₂₆F₃NO₃

Molecular Weight: 457.49

Cell-Permeable?: Yes

Purity: ≥98%

Solubilities: >25 mg/ml (DMSO) in 0

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A sphingosine-1-phosphate-1 (S1P1) receptor antagonist

MDL Number: N/A

PubChem CID: 44623998

SMILES: C1CCC(C1)C2=C(C=C(C=C2)COC3=CC4=C(C=C3)NC5=C4CCC5CC(=O)O)C(F)(F)F

InChi: InChI=1S/C26H26F3NO3/c27-26(28,29)22-11-15(5-8-19(22)16-3-1-2-4-16)14-33-18-7-10-23-21(13-18)20-9-6-17(12-24(31)32)25(20)30-23/h5,7-8,10-11,13,16-17,30H,1-4,6,9,12,14H2,(H,31,32)/t17-/m1/s1

InChi Key: MVGWUTBTXDYMND-QGZVFWFLSA-N