Description
A structural analog of EUK 8 and EUK 134 with significantly reduced activity. Acts as a synthetic catalytic scavenger of reactive oxygen species with superoxide dismutase (SOD) and catalase mimetic activity. Superoxide-mediated reduction of an electron acceptor (i.e., SOD mimetic activity) was inhibited by EUK 118 with an IC₅₀ value of 2.0 µm.
EUK-118 is a structural analog of EUK 8 and EUK 134 with significantly reduced activity. Acts as a synthetic catalytic scavenger of reactive oxygen species with superoxide dismutase (SOD) and catalase mimetic activity. Superoxide-mediated reduction of an electron acceptor (i.e., SOD mimetic activity) was inhibited by EUK 118 with an IC₅₀ value of 2.0 µm.
Alternate Name/Synonyms: (acetato-κO)[[2,2'-[1,2-ethanediylbis[(nitrilo-κN)methylidyne]]bis[3,5-dimethoxyphenolato-κO]](2-)]-manganese
Appearance: Off-white solid
Formulation: N/A
CAS Number: 186299-34-3
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₂H₂₅MnN₂O₈
Molecular Weight: 500.38
Cell-Permeable?: Yes
Purity: ≥95%
Solubilities: DMSO (~ 20 mg/ml)
Handling: Protect from air and moisture
Country of Origin: USA
Tag Line: A SOD and catalase mimetic
MDL Number: N/A
PubChem CID: N/A
SMILES: CC(=O)[O-][Mn]123([N+](=Cc4c(cc(cc4OC)OC)[O-]1)CC[N+]2=Cc5c(cc(cc5OC)OC)[O-]3)[Mn][Mn+]
InChi: InChI=1S/C20H24N2O6.C2H4O2.3Mn/c1-25-13-7-17(23)15(19(9-13)27-3)11-21-5-6-22-12-16-18(24)8-14(26-2)10-20(16)28-4;1-2(3)4;;;/h7-12,23-24H,5-6H2,1-4H3;1H3,(H,3,4);;;/q;;;+1;+2/p-3/b21-11+,22-12+;;;;
InChi Key: NKZPUKNJLPQHHM-CAGONKBASA-K
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
24months |