EUK-118 | 2173

A structural analog of EUK 8 and EUK 134 with significantly reduced activity. Acts as a synthetic catalytic scavenger of reactive oxygen species with superoxide dismutase (SOD) and catalase mimetic activity. Superoxide-mediated reduction of an electron acceptor (i.e., SOD mimetic activity) was inhibited by EUK 118 with an IC₅₀ value of 2.0 µm.

EUK-118 is a structural analog of EUK 8 and EUK 134 with significantly reduced activity. Acts as a synthetic catalytic scavenger of reactive oxygen species with superoxide dismutase (SOD) and catalase mimetic activity. Superoxide-mediated reduction of an electron acceptor (i.e., SOD mimetic activity) was inhibited by EUK 118 with an IC₅₀ value of 2.0 µm.

2173 | EUK-118 DataSheet

Alternate Name/Synonyms: (acetato-​κO)[[2,​2'-​[1,​2-​ethanediylbis[(nitrilo-​κN)methylidyne]]bis[3,​5-​dimethoxyphenolato-​κO]](2-​)]-​manganese

Appearance: Off-white solid

Formulation: N/A

CAS Number: 186299-34-3

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₂H₂₅MnN₂O₈

Molecular Weight: 500.38

Cell-Permeable?: Yes

Purity: ≥95%

Solubilities: DMSO (~ 20 mg/ml)

Handling: Protect from air and moisture

Country of Origin: USA

Tag Line: A SOD and catalase mimetic

MDL Number: N/A

PubChem CID: N/A

SMILES: CC(=O)[O-][Mn]123([N+](=Cc4c(cc(cc4OC)OC)[O-]1)CC[N+]2=Cc5c(cc(cc5OC)OC)[O-]3)[Mn][Mn+]

InChi: InChI=1S/C20H24N2O6.C2H4O2.3Mn/c1-25-13-7-17(23)15(19(9-13)27-3)11-21-5-6-22-12-16-18(24)8-14(26-2)10-20(16)28-4;1-2(3)4;;;/h7-12,23-24H,5-6H2,1-4H3;1H3,(H,3,4);;;/q;;;+1;+2/p-3/b21-11+,22-12+;;;;

InChi Key: NKZPUKNJLPQHHM-CAGONKBASA-K