Euphol | B3301

Euphol is a naturally occurring tetracyclic triterpene that displays anti-inflammatory action. Euphol produces anti-inflammatory effects by mediating NF-κB, down-regulation of tumor necrosis factor-α and cyclooxygenase-2 and reduced activation of protein kinase C. Euphol inhibits the monoacylglycerol lipase (MAGL) activity via a reversible mechanism (IC50=315nM). MAGL inhibition in the periphery modulates the endocannabinoid system to block the development of inflammatory pain Also acts as an inhibitor the of SARS-CoV-2 main protease (MPro monomer, 6m03).

Euphol is a naturally occurring tetracyclic triterpene that displays anti-inflammatory action. Euphol produces anti-inflammatory effects by mediating NF-κB, down-regulation of tumor necrosis factor-α and cyclooxygenase-2 and reduced activation of protein kinase C. Euphol inhibits the monoacylglycerol lipase (MAGL) activity via a reversible mechanism (IC50=315nM). MAGL inhibition in the periphery modulates the endocannabinoid system to block the development of inflammatory pain Also acts as an inhibitor the of SARS-CoV-2 main protease (MPro monomer, 6m03).

B3301 | Euphol DataSheet

Alternate Name/Synonyms: NSC 36571 (+)-Eupha-8,24-dien-3β-ol Euphadienol (+)-Euphol

Appearance: White solid

Formulation:

CAS Number: 514-47-6

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₃₀H₅₀O

Molecular Weight: 426.72

Cell-Permeable?: TRUE

Purity: ≥98% by HPLC

Solubilities: ~5 mg/ml DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A biologically active triterpene

MDL Number: MFCD01716323

PubChem CID: 441678

SMILES: CC(CCC=C(C)C)C1CCC2(C1(CCC3=C2CCC4C3(CCC(C4(C)C)O)C)C)C

InChi: InChI=1S/C30H50O/c1-20(2)10-9-11-21(3)22-14-18-30(8)24-12-13-25-27(4,5)26(31)16-17-28(25,6)23(24)15-19-29(22,30)7/h10,21-22,25-26,31H,9,11-19H2,1-8H3/t21-,22+,25+,26+,28-,29+,30-/m1/s1

InChi Key: CAHGCLMLTWQZNJ-WZLOIPHISA-N