Evacetrapib | 2558

Evacetrapib is a potent, and selective CETP (cholesteryl ester transfer protein) inhibitor. It inhibits human recombinant CETP protein (IC₅₀ = 5.5 nM ) and CETP activity in human plasma (IC₅₀ = 36 nM) in vitro. Unlike Torcetrapib (Cat. No. 2420 & 2533), Evacetrapib does not induce aldosterone or cortisol biosynthesis.

Evacetrapib is a potent, and selective CETP (cholesteryl ester transfer protein) inhibitor. It inhibits human recombinant CETP protein (IC₅₀ = 5.5 nM ) and CETP activity in human plasma (IC₅₀ = 36 nM) in vitro. Unlike Torcetrapib (Cat. No. 2420 & 2533), Evacetrapib does not induce aldosterone or cortisol biosynthesis.

2558 | Evacetrapib DataSheet

Alternate Name/Synonyms: trans-4-[[(5S)-5-[[[3,5-bis(trifluoromethyl)phenyl]methyl](2-methyl-2H-tetrazol-5-yl)amino]-2,3,4,5-tetrahydro-7,9-dimethyl-1H-1-benzazepin-1-yl]methyl]- cyclohexanecarboxylic acid; LY2484595

Appearance: Crystalline solid

Formulation: N/A

CAS Number: 1186486-62-3

Structure Available?: Y

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₃₁H₃₆F₆N₆O₂

Molecular Weight: 638.65

Cell-Permeable?: Yes

Purity: ≥95% by HPLC

Solubilities: DMSO (>10 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent and selective CETP inhibitor

MDL Number: N/A

PubChem CID: 49836058

SMILES: CC1=CC(=C2C(=C1)C(CCCN2CC3CCC(CC3)C(=O)O)N(CC4=CC(=CC(=C4)C(F)(F)F)C(F)(F)F)C5=NN(N=N5)C)C

InChi: InChI=1S/C31H36F6N6O2/c1-18-11-19(2)27-25(12-18)26(5-4-10-42(27)16-20-6-8-22(9-7-20)28(44)45)43(29-38-40-41(3)39-29)17-21-13-23(30(32,33)34)15-24(14-21)31(35,36)37/h11-15,20,22,26H,4-10,16-17H2,1-3H3,(H,44,45)/t20?,22?,26-/m0/s1

InChi Key: IHIUGIVXARLYHP-UXNJHFGPSA-N