EW-7197 | B1191

EW-7197 is a potent ALK5 (TGF-β Type I receptor) inhibitor that displays anti metastatic activity in vivo. In vivo mice experiments show EW-7197 repeals TGF- β1 induced tumor cell migration and invasion inhibiting breast cancer metastasis to the lung. It prolongs the life span of BALB/c4T1 mice by inhibiting metastasis and enhancing the activity of cytotoxic T lymphocytes (CTLs) in 4T1 orthotropic grafted mice.

EW-7197 is a potent ALK5 (TGF-β Type I receptor) inhibitor that displays anti metastatic activity in vivo. In vivo mice experiments show EW-7197 repeals TGF- β1 induced tumor cell migration and invasion inhibiting breast cancer metastasis to the lung. It prolongs the life span of BALB/c4T1 mice by inhibiting metastasis and enhancing the activity of cytotoxic T lymphocytes (CTLs) in 4T1 orthotropic grafted mice.

B1191 | EW-7197 DataSheet

Alternate Name/Synonyms: N-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)-2-fluoroaniline

Appearance: White Solid

Formulation: N/A

CAS Number: 1352608-82-2

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₂H₁₈FN₇

Molecular Weight: 399.42

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>75 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent ALK5 inhibitor

MDL Number:

PubChem CID: 54766013

SMILES: CC1=CC=CC(=N1)C2=C(N=C(N2)CNC3=CC=CC=C3F)C4=CN5C(=NC=N5)C=C4

InChi: InChI=1S/C22H18FN7/c1-14-5-4-8-18(27-14)22-21(15-9-10-20-25-13-26-30(20)12-15)28-19(29-22)11-24-17-7-3-2-6-16(17)23/h2-10,12-13,24H,11H2,1H3,(H,28,29)

InChi Key: FJCDSQATIJKQKA-UHFFFAOYSA-N