EX-229 | B2434

EX-229 is a potent and allosteric activator of AMP-activated protein kinase (AMPK). In rat epitrochlearis muscle, ex229 dose-dependently increases AMPK activity of α1-, α2-, β1- and β2-containing complexes with significant increases in AMPK activity seen at a concentration of 50 μM.

EX-229 is a potent and allosteric activator of AMP-activated protein kinase (AMPK). In rat epitrochlearis muscle, ex229 dose-dependently increases AMPK activity of α1-, α2-, β1- and β2-containing complexes with significant increases in AMPK activity seen at a concentration of 50 μM.

B2434 | EX-229 DataSheet

Alternate Name/Synonyms: EX229, AMPK Activator 991, 5-{[6-chloro-5-(1-methylindol-5-yl)-1H-benzimidazol-2-yl]oxy}-2-methyl-benzoic acid

Appearance: Off-white solid

Formulation:

CAS Number: 1219739-36-2

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₄H₁₈ClN₃O₃

Molecular Weight: 431.87

Cell-Permeable?: True

Purity: ≥98% by HPLC

Solubilities: >5 mg/ml DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A potent AMPK activator

MDL Number:

PubChem CID: 45256693

SMILES: CC1=C(C=C(C=C1)OC2=NC3=C(N2)C=C(C(=C3)C4=CC5=C(C=C4)N(C=C5)C)Cl)C(=O)O

InChi: InChI=1S/C24H18ClN3O3/c1-13-3-5-16(10-17(13)23(29)30)31-24-26-20-11-18(19(25)12-21(20)27-24)14-4-6-22-15(9-14)7-8-28(22)2/h3-12H,1-2H3,(H,26,27)(H,29,30)

InChi Key: FHWSAZXFPUMKFL-UHFFFAOYSA-N