EYA1 Antibody (N-term) [APR30952G]

EYA1 Antibody (N-term) [APR30952G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: M

Specificity: This EYA1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human EYA1.

Cellular Localisation: Cytoplasm. Nucleus Note=Localizes at sites of DNA damage at double-strand breaks (DSBs)

Molecular Weight: 64593

Clone: Polyclonal

Gene Name: EYA1

Gene ID: 2138

Function: Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for SIX2, SIX4 and SIX5 (By similarity) . Tyrosine phosphatase that dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1. 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress (PubMed:19234442) . Its function as histone phosphatase may contribute to its function in transcription regulation during organogenesis (By similarity) . Has also phosphatase activity with proteins phosphorylated on Ser and Thr residues (in vitro) (By similarity) . Required for normal embryonic development of the craniofacial and trunk skeleton, kidneys and ears (By similarity) . Together with SIX1, it plays an important role in hypaxial muscle development; in this it is functionally redundant with EYA2 (By similarity) .

Summary: Tissue Location: In the embryo, highly expressed in kidney with lower levels in brain. Weakly expressed in lung. In the adult, highly expressed in heart and skeletal muscle. Weakly expressed in brain and liver. No expression in eye or kidney

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: Eyes absent homolog 1, EYA1