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EZCyp™ Active Human Cytochrome P450 3A4 | 7872
- SKU:
- 26-7872-GEN
- Availability:
- Usually shipped in 5 working days
Description
Cytochrome P450 3A4 (CYP3A4, EC 1.14.13.157) is a member of the cytochrome P450 monooxidase (CYP) family of microsomal xenobiotic metabolism enzymes. CYPs are membrane-bound hemeproteins responsible for Phase I biotransformation reactions, in which lipophilic drugs and other xenobiotic compounds are transformed to more hydrophilic products to facilitate excretion from the body. CYP3A4 is expressed in high levels in the liver and intestines, where it catalyzes oxidation of an extraordinarily wide variety of structurally distinct ligands. More than half of all small molecule drugs commonly used by humans are metabolized by CYP3A4. s EZCypTM 3A4 is a permeabilized and stabilized dried yeast powder preparation containing recombinant human CYP 3A4 and recombinant human P450 NADPH oxidoreductase co expressed in the same preparation.
7872 | EZCyp Active Human Cytochrome P450 3A4 DataSheet
Biomolecule/Target: EZCyp™ Active Human CYP3A4
Synonyms: Cytochrome P450 3A, Cytochrome P450 3A4, Cyt3A4, CYPIIIA, CYPIIIA4, CYP3A, CYP3A4, Microsomal cytochrome P450 3A4, active CYP3A, human cyp3a, human CYP3A4, recombinant human CYP3A4
Alternates names: Vascular Endothelial Growth Factor-C, VEGFC, Flt4 ligand
Taglines: Unique, cost-effective CYP3A4 catalytic system with active recombinant human CYP3A4 coexpressed with the active NADPH reductase in a semipermeable membrane system.
NCBI Gene ID #: 22341
NCBI Gene Symbol: VEGFC
Gene Source: Human
Accession #: P97953
Recombinant: Yes
Source: Pichia pastoris
Purity by SDS-PAGEs: 90%
Assay: N/A
Purity: NA
Assay #2: NA
Endotoxin Level: NA
Activity (Specifications/test method): K701, Metabolite HPLC
Biological activity: Testing in progress
Results: NA
Binding Capacity: NA
Unit Definition: NA
Molecular Weight: 15.0 kDa
Concentration: N/A
Appearance: Dry powder
Physical form description: Lyophilized powder
Reconstitution Instructions: Reconstitute in 0.1% acetic acid to a concentration of 0.1-1.0 mg/ml
Amino acid sequence: N/A