EZH2 Inhibitor, EPZ005687 | 2364

A potent and selective inhibitor of histone lysine N-methyltransferase EZH2 (Ki = 24 nM). It displays more than 500-fold selectivity against 15 other protein methyltransferases and has 50-fold selectivity against the closely related enzyme, EZH1.

A potent and selective inhibitor of histone lysine N-methyltransferase EZH2 (Ki = 24 nM).

2364 | EZH2 Inhibitor, EPZ005687 DataSheet

Alternate Name/Synonyms: 1-Cyclopentyl-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-6-(4-(morpholinomethyl)phenyl)-1H-indazole-4-carboxamide

Appearance: White solid

Formulation: N/A

CAS Number: 1396772-26-1

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₃₂H₃₇N₅O₃

Molecular Weight: 539.67

Cell-Permeable?: No

Purity: ≥99%HPLC

Solubilities: DMSO

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent EZH2 inhibitor

MDL Number: N/A

PubChem CID: 60160561

SMILES: CC1=CC(=C(C(=O)N1)CNC(=O)C2=C3C=NN(C3=CC(=C2)C4=CC=C(C=C4)CN5CCOCC5)C6CCCC6)C

InChi: InChI=1S/C32H37N5O3/c1-21-15-22(2)35-32(39)28(21)18-33-31(38)27-16-25(17-30-29(27)19-34-37(30)26-5-3-4-6-26)24-9-7-23(8-10-24)20-36-11-13-40-14-12-36/h7-10,15-17,19,26H,3-6,11-14,18,20H2,1-2H3,(H,33,38)(H,35,39)

InChi Key: ZOIBZSZLMJDVDQ-UHFFFAOYSA-N