EZSolution™ BIX 01294 | 2661

A 10 mM (5 mg in 1019 µl) solution of the HMTase inhibitor BIX01294 (Cat. No. 1678) in anhydrous DMSO.

BIX01294 selectively impairs the G9a histone lysine methyltransferase (HMTase) and the generation of H3K9me2 in vitro. BIX-01294 enables neural progenitor cells (NPCs) to be reprogrammed in the absence of exogenous Oct4.

2661 | EZSolution™ BIX 01294 DataSheet

Alternate Name/Synonyms: 2-(Hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6,7-dimethoxy-N-[1-(phenylmethyl)-4-piperidinyl]-4-quinazolinamine

Appearance: Liquid

Formulation: A 10 mM solution in DMSO

CAS Number: 935693-62-2

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₈H₃₈N₆O₂

Molecular Weight: 490.65

Cell-Permeable?: Yes

Purity: ≥95% by HPLC

Solubilities: N/A

Handling: Protect from air and moisture

Country of Origin: USA

Tag Line: A G9a histone lysine methyltransferase (HMTase) inhibitor

MDL Number: MFCD14560563

PubChem CID: 25150857

SMILES: CN1CCCN(CC1)C2=NC3=CC(=C(C=C3C(=N2)NC4CCN(CC4)CC5=CC=CC=C5)OC)OC

InChi: InChI=1S/C28H38N6O2/c1-32-12-7-13-34(17-16-32)28-30-24-19-26(36-3)25(35-2)18-23(24)27(31-28)29-22-10-14-33(15-11-22)20-21-8-5-4-6-9-21/h4-6,8-9,18-19,22H,7,10-17,20H2,1-3H3,(H,29,30,31)

InChi Key: OSXFATOLZGZLSK-UHFFFAOYSA-N