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EZSolution™ Cerdulatinib | B2482
- SKU:
- 26-B2482-GEN
- Availability:
- Usually shipped in 5 working days
Description
A 10 mM (5 mg in 1.12 ml) solution of the potent Syk and JAK inhibitor Cerdulatinib (Cat. No. 2803) in anhydrous DMSO.
Cerdulatinib is a novel, dual spleen tyrosine kinase (Syk) and janus kinase (JAK) inhibitor. It preferentially inhibits JAK1 and JAK3 dependent cytokine mediated signaling and functional responses in various cell types. IL2 mediated STAT5 Y694 is inhibited with an IC₅₀ of 0.27 μM, while IL4 mediated signaling to STAT6 Y641 and functional responses in B cells and monocytes, namely CD69, CD25, and CD23 up-regulation, are inhibited with IC₅₀’s within the range of 0.11 μM to 0.57 μM.
B2482 | EZSolution™ Cerdulatinib DataSheet
Alternate Name/Synonyms: 4-(cyclopropylamino)-2-[[4-[4-(ethylsulfonyl)-1-piperazinyl]phenyl]amino]-5-pyrimidinecarboxamide, PRT062070, PRT2070
Appearance: Liquid
Formulation: A 10 mM solution in anhydrous DMSO
CAS Number: 1198300-79-6
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₀H₂₇N₇O₃S
Molecular Weight: 445.54
Cell-Permeable?: True
Purity: ≥98% by HPLC
Solubilities:
Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Country of Origin: USA
Tag Line: A novel, dual spleen tyrosine kinase (Syk) and janus kinase (JAK) inhibitor
MDL Number:
PubChem CID: 44595079
SMILES: CCS(=O)(=O)N1CCN(CC1)C2=CC=C(C=C2)NC3=NC=C(C(=N3)NC4CC4)C(=O)N
InChi: InChI=1S/C20H27N7O3S/c1-2-31(29,30)27-11-9-26(10-12-27)16-7-5-15(6-8-16)24-20-22-13-17(18(21)28)19(25-20)23-14-3-4-14/h5-8,13-14H,2-4,9-12H2,1H3,(H2,21,28)(H2,22,23,24,25)
InChi Key: BGLPECHZZQDNCD-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20ºC |
Shipping Condition: |
Gel Pack |
Shelf Life: |
24months |