Description
A potent necroptosis inhibitor. Displays higher activity in inhibiting necroptosis in Jurkat cells than Nec-1 (Cat. No. 1864) (EC₅₀ = 210 nM versus EC₅₀ = 490 nM), as well as showing no nonspecific cytotoxicity at high concentrations (~100 mM). More useful for in-cell and in vivo experiments compared to Nec-1.
EZSolution™ Nec-1s is a 10 mM (1 mg in 360 µl) solution of the necroptosis inhibitor Nec-1s (Cat. No. 2263) in anhydrous DMSO.
2535 | EZSolution™ Nec-1s DataSheet
Alternate Name/Synonyms: 5-((7-Cl-1H-indol-3-yl)methyl)-3-methylimidazolidine-2,4-dione); 7-Cl-O-Nec-1
Appearance: Liquid
Formulation: A 10 mM solution in anhydrous DMSO
CAS Number: N/A
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₁₃H₁₂ClN₃O₂
Molecular Weight: 277.71
Cell-Permeable?: Yes
Purity: ≥96% by LC-MS
Solubilities: N/A
Handling: Protect from light and moisture
Country of Origin: USA
Tag Line: A potent necroptosis inhibitor
MDL Number: N/A
PubChem CID: 643953
SMILES: CN1C(=O)C(NC1=O)CC2=CNC3=C2C=CC=C3Cl
InChi: InChI=1S/C13H12ClN3O2/c1-17-12(18)10(16-13(17)19)5-7-6-15-11-8(7)3-2-4-9(11)14/h2-4,6,10,15H,5H2,1H3,(H,16,19)
InChi Key: WIKGAEMMNQTUGL-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
12 months |