EZSolution™ Necrosulfonamide, Sterile-Filtered | B1220

A 10 mM (10 mg in 2.17 ml), sterile-filtered solution of the necroptosis inhibitor Necrosulfonamide (Cat. No. 9635) in anhydrous DMSO.

Necrosulfonamide is a potent necroptosis inhibitor. It blocks mixed lineage kinase domain-like protein (MLKL), a critical substrate of receptor-interacting serine-threonine kinase 3 (RIP3) during necrosis. Prevents MLKL-RIP1-RIP3 necrosome complex from interacting with downstream necrosis effectors. Unlike Necrostatin-1 (Cat. No. 1864), NSA does not inhibit the necrosis-induced RIP1 and RIP3 interactions.

B1220 | EZSolution™ Necrosulfonamide, Sterile-Filtered DataSheet

Alternate Name/Synonyms: (2E)-N-[4-[[(3-Methoxy-2-pyrazinyl)amino]sulfonyl]phenyl]-3-(5-nitro-2-thienyl)-2-propenamide; NSA

Appearance: Liquid

Formulation: A 10 mM sterile-filtered solution in DMSO

CAS Number: 1360614-48-7

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₈H₁₅N₅O₆S₂

Molecular Weight: 461.47

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: N/A

Handling: Protect from air and moisture

Country of Origin: USA

Tag Line: A potent necroptosis inhibitor

MDL Number: N/A

PubChem CID: 1566236

SMILES: COC1=NC=CN=C1NS(=O)(=O)C2=CC=C(C=C2)NC(=O)C=CC3=CC=C(S3)[N+](=O)[O-]

InChi: InChI=1S/C18H15N5O6S2/c1-29-18-17(19-10-11-20-18)22-31(27,28)14-6-2-12(3-7-14)21-15(24)8-4-13-5-9-16(30-13)23(25)26/h2-11H,1H3,(H,19,22)(H,21,24)/b8-4+

InChi Key: FNPPHVLYVGMZMZ-XBXARRHUSA-N