EZSolution™ RS-1 | B1876

A 10 mM (5.0 mg in 954 μl), sterile-filtered solution of the HDR (homology-directed repair) enhancer RS-1 (Cat. No. B1118) in anhydrous DMSO.

RS-1 (RAD51-stimulatory compound 1) is a high affinity stimulator of the human homologous recombination (HR) protein RAD51. RS-1 stimulates binding of hRAD51 to single stranded DNA (ssDNA) and enhances recombinogenic activity by stabilizing the active form of hRAD51 filaments without inhibiting hRAD51 ATPase activity. RS-1 has been shown to enhance CRISPR-Cas9 knock-in efficiency in HEK293A cells and has been shown to enhance both TALEN and Cas9-mediated knock-in efficiency in rabbits.

B1876 | EZSolution™ RS-1 DataSheet

Alternate Name/Synonyms: 4-Bromo-N-(4-bromophenyl)-3-[[(phenylmethyl)amino]sulfonyl]benzamide

Appearance: Liquid

Formulation: A 10 mM solution in DMSO

CAS Number: 312756-74-4

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₀H₁₆Br₂N₂O₃S

Molecular Weight: 524.23

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: N/A

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A RAD51 stimulator and HDR enhancer

MDL Number: MFCD00348720

PubChem CID: 1039737

SMILES: C1=CC=C(C=C1)CNS(=O)(=O)C2=C(C=CC(=C2)C(=O)NC3=CC=C(C=C3)Br)Br

InChi: InChI=1S/C20H16Br2N2O3S/c21-16-7-9-17(10-8-16)24-20(25)15-6-11-18(22)19(12-15)28(26,27)23-13-14-4-2-1-3-5-14/h1-12,23H,13H2,(H,24,25)

InChi Key: SWKAVEUTKGKHSR-UHFFFAOYSA-N