EZSolution™ Ruxolitinib | B2477

A 10 mM (5 mg in 1.63 ml) solution of the potent JAK inhibitor Ruxolitinib (Cat. No. 2139) in anhydrous DMSO.

Ruxolitinib is a potent and selective Janus kinase (JAK) inhibitor with IC₅₀'s of 2.7 and 4.5 nM for JAK1 and JAK2, respectively. Displays clinically significant activity in myelofibrosis.

B2477 | EZSolution™ Ruxolitinib DataSheet

Alternate Name/Synonyms: NCB18424; βR-cyclopentyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazole-1-propanenitrile; INC18424; INCB 018424

Appearance: Liquid

Formulation: A 10 mM solution in anhydrous DMSO

CAS Number: 941678-49-5

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₇H₁₈N₆

Molecular Weight: 306.37

Cell-Permeable?: True

Purity: ≥98% by HPLC

Solubilities:

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A potent JAK inhibitor

MDL Number:

PubChem CID: 25126798

SMILES: C1CCC(C1)C(CC#N)N2C=C(C=N2)C3=C4C=CNC4=NC=N3

InChi: InChI=1S/C17H18N6/c18-7-5-15(12-3-1-2-4-12)23-10-13(9-22-23)16-14-6-8-19-17(14)21-11-20-16/h6,8-12,15H,1-5H2,(H,19,20,21)/t15-/m1/s1

InChi Key: HFNKQEVNSGCOJV-OAHLLOKOSA-N