EZSolution™ SCR7 pyrazine | B1877

A 10 mM (5.0 mg in 1.50 ml), sterile-filtered solution of the HDR (homology-directed repair) enhancer SCR7 Pyrazine (Cat. No. B1119) in anhydrous DMSO.

SCR7 pyrazine is a potent inhibitor of nonhomologous endjoining (NHEJ) mediated by DNA ligase IV. Enhances CRISPR-Cas9-mediated homology-directed repair (HDR) efficiency in vitro.

B1877 | EZSolution™ SCR7 pyrazine DataSheet

Alternate Name/Synonyms: 2,3-Dihydro-6,7-diphenyl-2-thioxo-4(1H)-pteridinone

Appearance: Liquid

Formulation: A 10 mM solution in DMSO

CAS Number: 14892-97-8

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₈H₁₂N₄OS

Molecular Weight: 332.38

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: N/A

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A DNA ligase IV inhibitor and HDR enhancer

MDL Number: MFCD02167478

PubChem CID: 10688007

SMILES: C1=CC=C(C=C1)C2=NC3=C(NC(=S)NC3=O)N=C2C4=CC=CC=C4

InChi: InChI=1S/C18H12N4OS/c23-17-15-16(21-18(24)22-17)20-14(12-9-5-2-6-10-12)13(19-15)11-7-3-1-4-8-11/h1-10H,(H2,20,21,22,23,24)

InChi Key: GSRTWXVBHGOUBU-UHFFFAOYSA-N