Description
F3 Antibody | 15-199 | Gentaur UK, US & Europe Distribution
Host: Rabbit
Reactivity: Human, Rat
Homology: N/A
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 120-251 of human F3 (NP_001984.1) .
Research Area: Immunology
Tested Application: WB, IHC
Application: WB: 1:500 - 1:2000
IHC: 1:50 - 1:200
Specificiy: N/A
Positive Control 1: NCI-H460
Positive Control 2: SW480
Positive Control 3: HL-60
Positive Control 4: SKOV3
Positive Control 5: N/A
Positive Control 6: N/A
Molecular Weight: Observed: 45kDa
Validation: N/A
Isoform: N/A
Purification: Affinity purification
Clonality: Polyclonal
Clone: N/A
Isotype: IgG
Conjugate: Unconjugated
Physical State: Liquid
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Concentration: N/A
Storage Condition: Store at -20˚C. Avoid freeze / thaw cycles.
Alternate Name: CD142, TF, TFA, tissue factor, coagulation factor III (thromboplastin, tissue factor)
User Note: Optimal dilutions for each application to be determined by the researcher.
BACKGROUND: This gene encodes coagulation factor III which is a cell surface glycoprotein. This factor enables cells to initiate the blood coagulation cascades, and it functions as the high-affinity receptor for the coagulation factor VII. The resulting complex provides a catalytic event that is responsible for initiation of the coagulation protease cascades by specific limited proteolysis. Unlike the other cofactors of these protease cascades, which circulate as nonfunctional precursors, this factor is a potent initiator that is fully functional when expressed on cell surfaces. There are 3 distinct domains of this factor: extracellular, transmembrane, and cytoplasmic. This protein is the only one in the coagulation pathway for which a congenital deficiency has not been described. Alternate splicing results in multiple transcript variants.