F8 | Coagulation factor VIII | IMS01-015-308

F8 | Coagulation factor VIII | IMS01-015-308 | Gentaur UK, US & Europe Distribution

Immunogen: purified full length native human Coagulation Factor VIII-VWF-F VIII:c complex

Host: Chicken

Conjugation: N/A

Clonality: Polyclonal

Isotype: N/A

Purity: Purified, total IgY (chicken egg yolk immunoglobulin) in 0.9% NaCl, 0.02% sodium azide.

Format: Liquid

Tested Application: Total, purified IgY

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Recommended Dilutions: 1 : 200 (IHC)

Molecular weight: 267 kDa

Confirmed Reactivity: Human

Predicted Reactivity: Human

Not reactive in: No confirmed exceptions from predicted reactivity are currently known

Additional Information: Immunohistochemistry: antibody was tested on bonin-fixed rat blood vessel

Background: The factor VIII complex, with a molecular weight in excess of 1 million, has 2 components: (1) factor VIII P00451 (molecular weight of 267 kDa) called factor VIII C, when measured by procoagulant activity or factor VIII Ag, when measured immunologically; (2) factor VIII R P04275 (the von Willebrand factor or vWF) has a molecular weight of 225 kDa. Factor VIII, along with calcium and phospholipids, acts as a cofactor for factor IXa when it converts factor X to the activated form, factor Xa. Domain F5/8 type C 2 Is responsible for phospholipid binding and essential for factor VIII activity. Defects in F8 are the cause of hemophilia A (HEMA) . HEMA is a common recessive X-linked coagulation disorder.

Reconstitution: N/A

Storage: Store at 4°C; make aliquots to avoid working with a stock. Please remember to spin the tubes briefly prior to opening them to avoid any losses that might occur from material adhering to the cap or sides of the tube.

TAIR Nnumbre: N/A

Category: Immunology

Research Area: Immunology