FA83D Antibody (C-term) [APR03704G]

FA83D Antibody (C-term) [APR03704G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This FA83D antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 357-385 amino acids from the C-terminal region of human FA83D.

Cellular Localisation: Cytoplasm. Cytoplasm, cytoskeleton, spindle Cytoplasm, cytoskeleton, spindle pole. Note=Primarily cytoplasmic during interphase, but at prophase, associates with spindle microtubules, with a clear concentration toward the spindle poles. It persists on spindle microtubules through metaphase and anaphase

Molecular Weight: 64424

Clone: Polyclonal

Gene Name: FAM83D (HGNC:16122)

Gene ID: 81610

Function: Through the degradation of FBXW7, may act indirectly on the expression and downstream signaling of MTOR, JUN and MYC (PubMed:24344117) . May play also a role in cell proliferation through activation of the ERK1/ERK2 signaling cascade (PubMed:25646692) . May also be important for proper chromosome congression and alignment during mitosis through its interaction with KIF22 (PubMed:18485706) .

Summary: Tissue Location: Expressed in the testis.

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: Protein FAM83D, Spindle protein CHICA, FAM83D, C20orf129