Description
Factor XIIIa Polyclonal Antibody | E-AB-12903 | Gentaur UK, US & Europe Distribution
Type: Polyclonal Antibody
Synonyms: bA525O21.1 (coagulation factor XIII, A1 polypeptide), Coagulation factor XIII A chain, Coagulation factor XIII A1 polypeptide, Coagulation factor XIII A1 subunit, Coagulation factor XIII, A polypeptide, Coagulation factor XIIIa, F13A, F13A, F13a1, Factor XIIIA, Fibrin stabilizing factor, A subunit, Fibrinoligase, FSF, A subunit, Protein glutamine gamma glutamyltransferase A chain, Protein-glutamine gamma-glutamyltransferase A chain, TGase, Transglutaminase A chain, Transglutaminase, plasma, Transglutaminase. plasma
Application: IHC, ELISA
Reactivity: Human, Mouse, Rat
Host: Rabbit
Isotype: IgG
Reserch Areas: Cancer, Cardiovascular, Tags and Cell Markers
Background: This gene encodes the coagulation factor XIII A subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. It also crosslinks alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin.
Concentration: 0.1 mg/mL
Storage: Store at -20°C. Avoid freeze / thaw cycles.
Immunogen: Synthetic peptide of human F13A1
Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Purification Method: Affinity purification
Dilution: IHC 1:100-1:300
Clone: N/A
Conjugation: Unconjugated
Molecular Weight(Calculated): N/A
Molecular Weight(Observed): N/A