FAIM2 Antibody (Center) [APR31431G]

FAIM2 Antibody (Center) [APR31431G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This FAIM2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 76-105 amino acids from the Central region of human FAIM2.

Cellular Localisation: Cell membrane; Multi-pass membrane protein. Membrane raft Cell junction, synapse, postsynaptic cell membrane

Molecular Weight: 35110

Clone: Polyclonal

Gene Name: FAIM2

Gene ID: 23017

Function: Antiapoptotic protein which protects cells uniquely from Fas- induced apoptosis. Regulates Fas-mediated apoptosis in neurons by interfering with caspase-8 activation. May play a role in cerebellar development by affecting cerebellar size, internal granular layer (IGL) thickness, and Purkinje cell (PC) development.

Summary: Tissue Location: Highly expressed in breast carcinoma tissues. Enhanced expression correlates with the grade of the tumor (grade II/grade III) in primary breast tumors (at protein level) . Widely expressed. Expressed at high levels in the brain especially in the hippocampus.

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: Protein lifeguard 2, Fas apoptotic inhibitory molecule 2, Neural membrane protein 35, Transmembrane BAX inhibitor motif-containing protein 2, FAIM2, KIAA0950, LFG, LFG2, NMP35, TMBIM2