BW
FAK Rabbit monoclonal Antibody | BS9850M
- SKU:
- BW-BS9850M
- Availability:
- Usually ships in 5 working days
Description
FAK Rabbit monoclonal Antibody | BS9850M | Gentaur UK, US & Europe Distribution
Host: Rabbit
Reactivity: Human,Mouse,Rat
Application: WB ICC/IF IHC FC
Application Range: WB: 1:1000-1:2000 ICC/IF: 1:50-1:200 IHC: 1:50-1:200 FC: 1:50-1:100
Background: Focal adhesion kinase was initially identified as a major 125 kDa substrate for the intrinsic protein tyrosine kinase activity of Src-encoded pp60. The deduced amino acid sequence of FAK p125 has shown it to be a cytoplasmic protein tyrosine kinase whose sequence and structural organization are unique as compared to other proteins described to date. Localization of p125 by immunofluorescence suggests that it is primarily found in cellular focal adhesions leading to its designation as focal adhesion kinase (FAK) . FAK is concentrated at the basal edge of only basal keratinocytes that are actively migrating and rapidly proliferating in repairing burn wounds, and is activated and localized to the focal adhesions of spreading keratinocytes in culture.
Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: This Antibody detects endogenous levels of FAK and does not cross-react with related proteins.
Molecular Weight: ~ 125 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: Focal adhesion kinase 1; FADK 1; Focal adhesion kinase-related nonkinase; FRNK; Protein phosphatase 1 regulatory subunit 71; PPP1R71; Protein-tyrosine kinase 2; p125FAK; pp125FAK; PTK2; FAK; FAK1
Immunogen: Recombinant Antibody.
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: Protein A affinity purified
Pathway: Toll-like Receptor signaling,B cell receptor signaling,