Famotidine | 10-026

Famotidine | 10-026 | Gentaur UK, US & Europe Distribution

BNR: Chemical

Predicted Molecular Weight: 337, 5

Physical State: Lyophilized

Storage Condition: Short Term Storage: +4C. Long Term Storage: -20C. Handling Advice: Keep cool and dry. Protect from moisture. Use/Stability: Stable for at least 2 years after receipt when stored at -20C.

Alternate Name: MK-208; YM-11170; Pepcid; N′- (Aminosulfonyl) -3- ([2- (diaminomethyleneamino) -4-thiazolyl]methylthio) propanamidine

Background: Famotidine is a histamine H2 receptor antagonist. It is selective for H2 over H1 and muscarinic receptors (Kis = 4 and 28 µM, respectively, in bovine cerebral cortex) . Famotidine blocks the action of histamine in the parietal cells, ultimately blocking acid secretion in the stomach. It inhibits histamine-induced acid secretion in isolated canine parietal cells (IC50 = 0.6µM) and suppresses histamine-induced gastric acid secretion in dogs when administered orally and in anesthetized rats when administered intraduodenally (ID50s = 10 and 400µg/kg, respectively) . Famotidine is used to treat ulcers, gastroesophageal reflux disease (GERD) and heartburn and it decreases the risk of gastrointestinal toxicity associated with non-steroidal anti-inflammatory drugs (NSAIDs) . Potential inhibitor of the viral enzyme papain-like protease (PLpro), important for SARS-CoV-2 replication and being tested in COVID-19 clinical trials.

Disclaimer: This product is for research use only.

Purity: greater than or equal to 98% (HPLC)

Formula: C8H15N7O2S3

Source: N/A

Solubility: Soluble in DMSO (30mg/ml) or DMF (25mg/ml) .

InChi Key: XUFQPHANEAPEMJ-UHFFFAOYSA-N

Smiles: N/C (N) =N/C1=NC (CSCC/C (N) =N/S (=O) (N) =O) =CS1

RTECS: N/A

Identity: Determined by 1H-NMR.

Merck Index: N/A