Fangchinoline | B3240

Fangchinoline is a bisbenzylisoquinoline alkaloid that has been shown to elicit anti-cancer effects in prostate and breast cancer cell lines via inducing G1 cell cycle arrest. It has also been shown to inhibit cell proliferation and cell cycle progression in rat aortic vascular smooth muscle cells. Fangchinoline inhibits apoptosis of osteoblasts and protects against bone loss in prednisolone-induced osteoporosis rats by inducing autophagy.

Fangchinoline is a bisbenzylisoquinoline alkaloid that has been shown to elicit anti-cancer effects in prostate and breast cancer cell lines via inducing G1 cell cycle arrest. It has also been shown to inhibit cell proliferation and cell cycle progression in rat aortic vascular smooth muscle cells. Fangchinoline inhibits apoptosis of osteoblasts and protects against bone loss in prednisolone-induced osteoporosis rats by inducing autophagy.

B3240 | Fangchinoline DataSheet

Alternate Name/Synonyms: Limacine,Frangchinoline,7-O-Demethyltetrandine

Appearance: Solid

Formulation:

CAS Number: 436-77-1

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₃₇H₄₀N₂O₆

Molecular Weight: 608.72

Cell-Permeable?: True

Purity: ≥98%

Solubilities: ~25 mg/ml DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A biologically active bisbenzylisoquinoline alkaloid

MDL Number: MFCD03427706

PubChem CID: 73481

SMILES: CN1CCC2=CC(=C3C=C2C1CC4=CC=C(C=C4)OC5=C(C=CC(=C5)CC6C7=C(O3)C(=C(C=C7CCN6C)OC)O)OC)OC

InChi: InChI=1S/C37H40N2O6/c1-38-14-12-24-19-31(42-4)33-21-27(24)28(38)16-22-6-9-26(10-7-22)44-32-18-23(8-11-30(32)41-3)17-29-35-25(13-15-39(29)2)20-34(43-5)36(40)37(35)45-33/h6-11,18-21,28-29,40H,12-17H2,1-5H3/t28-,29-/m0/s1

InChi Key: IIQSJHUEZBTSAT-VMPREFPWSA-N