FAP1 polyclonal Antibody | BS90493

FAP1 polyclonal Antibody | BS90493 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human

Application: WB IHC

Application Range: WB:1:500-1:1,000 IHC:1:50-1:200

Background: FAP (fibroblast activation protein) is a cell surface glycoprotein and serine protease that is expressed primarily in fetal mesenchymal tissues and epithelial cancer fibroblasts. In cancer, FAP functions to promote cellular proliferation. In embryonic development, FAP functions to remodel developing tissues. FAP acts as an integral membrane gelatinase composed of N-glycosylated proteolytically inactive subunits. FAP expression on chondrocyte membranes is upregulated by the combination of the cytokines IL-1 and OSM and has been shown to increase in osteoarthritic patients. This expression is co-localized with MMP-1and MMP-13 as well as CD44 (variants v3 and v7/8) . Mice that lack all copies of the FAP gene have been found to be fertile and to have developmental defects or change in cancer susceptibility.

Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: FAP1 polyclonal Antibody detects endogenous levels of FAP1 protein.

Molecular Weight: 95 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: FAPalpha, SIMP, Seprase, FAP, APO1/CD95 (Fas) associated phosphatase, DKFZp686J1497, FAP 1, FAP1, Fas associated phosphatase 1, Fas associated protein tyrosine phosphatase 1, HGNC:9646, hPTPE1, Phosphatase rip, PNP 1, PNP1, Protein tyrosine phosphatase 1 Fas associated, protein tyrosine phosphatase 1E, Protein tyrosine phosphatase non receptor type 13, Protein tyrosine phosphatase nonreceptor type 13, Protein tyrosine phosphatase PTPL1, protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas) -associated phosphatase), PTP BAS, PTP BL, PTP E1, PTP1E, PTPL 1, PTPL1, PTPLE, PTPN 13, PTPN13, Tyrosine protein phosphatase non receptor type 13,

Immunogen: recombinant protein

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: ProA affinity purified

Pathway: