Fas Ligand Antibody [SB93a] (FITC) | 99-787

Fas Ligand Antibody [SB93a] (FITC) | 99-787 | Gentaur UK, US & Europe Distribution

Host: Mouse

Reactivity: Human, Chicken

Homology: N/A

Immunogen: Recombinant human Fas ligand

Research Area: Apoptosis

Tested Application: IHC-Fr, FLISA

Application: Fas Ligand Antibody [SB93a] for use in flow cytometry, immunohistochemistry, and western blotting assays.

Specificiy: Fas Ligand

Positive Control 1: N/A

Positive Control 2: N/A

Positive Control 3: N/A

Positive Control 4: N/A

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: N/A

Validation: N/A

Isoform: N/A

Purification: N/A

Clonality: Monoclonal

Clone: [SB93a]

Isotype: IgG2b

Conjugate: FITC

Physical State: Liquid

Buffer: Supplied in PBS/NaN3

Concentration: 0.5 mg/mL

Storage Condition: Store vial at 2-8˚C

Alternate Name: FasL, CD178, CD95L, TNFSF6

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: Fas ligand (CD178) is a 40 kD type II transmembrane protein that is a member of the tumor necrosis factor superfamily. This well characterized potent apoptotic factor is utilized by cytotoxic T cells and natural killer cells to selectively kill virus infected and tumorigenic cells. Moreover, studies indicate that Fas ligand is an important regulator in immune homeostasis where it has been shown to down-regulate immune responses during activation-induced cell death. Fas ligand initiates apoptosis by binding to its receptor, CD95, on target cells which facilitates recruitment of numerous signaling proteins to form a death inducing signaling complex. This signaling complex is then believed to propagate the apoptotic signal through the recruitment and activation of caspase-8. The SB93a monoclonal antibody detects a band at ~40 kDa corresponding to the transmembrane/insoluble form of Fas ligand.