26
Fasudil, Monohydrochloride | 1787
- SKU:
- 26-1787-GEN
- Availability:
- Usually shipped in 5 working days
Description
A cell-permeable Ca²⁺ antagonist and vasodilator. Inhibits protein kinase A (Ki = 1.6 µM), protein kinase G (Ki = 1.6 µM), myosin light chain kinase (Ki = 36 µM) and Rho kinase (ROCK; IC₅₀ = 10.7 µM. Fasudil also mobilizes adult neural stem cells in vivo.
Fasudil, Monohydrochloride is a cell-permeable Ca²⁺ antagonist and vasodilator. Inhibits protein kinase A (Ki = 1.6 µM), protein kinase G (Ki = 1.6 µM), myosin light chain kinase (Ki = 36 µM) and Rho kinase (ROCK; IC₅₀ = 10.7 µM).
1787 | Fasudil, Monohydrochloride DataSheet
Alternate Name/Synonyms: 1-(5-Isoquinolinesulfonyl)homopiperazine, Monohydrochloride Salt; HA-1077, Monohydrochloride; AT-877
Appearance: White to off-white solid
Formulation: Water (175 mg/ml) or DMSO (10 mg/ml)
CAS Number: 105628-07-7
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₁₄H₁₇N₃O₂S•HCl
Molecular Weight: 327.83
Cell-Permeable?: Yes
Purity: ≥99% by HPLC
Solubilities: Water (175 mg/ml) or DMSO (10 mg/ml)
Handling: Protect from air and moisture
Country of Origin: USA
Tag Line: A Rho kinase (ROCK) inhibitor
MDL Number: MFCD00943198
PubChem CID: 163751
SMILES: C1CNCCN(C1)S(=O)(=O)C2=CC=CC3=C2C=CN=C3.Cl
InChi: InChI=1S/C14H17N3O2S.ClH/c18-20(19,17-9-2-6-15-8-10-17)14-4-1-3-12-11-16-7-5-13(12)14;/h1,3-5,7,11,15H,2,6,8-10H2;1H
InChi Key: LFVPBERIVUNMGV-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
48 months |