Fasudil, Monohydrochloride | 1787

A cell-permeable Ca²⁺ antagonist and vasodilator. Inhibits protein kinase A (Ki = 1.6 µM), protein kinase G (Ki = 1.6 µM), myosin light chain kinase (Ki = 36 µM) and Rho kinase (ROCK; IC₅₀ = 10.7 µM. Fasudil also mobilizes adult neural stem cells in vivo.

Fasudil, Monohydrochloride is a cell-permeable Ca²⁺ antagonist and vasodilator. Inhibits protein kinase A (Ki = 1.6 µM), protein kinase G (Ki = 1.6 µM), myosin light chain kinase (Ki = 36 µM) and Rho kinase (ROCK; IC₅₀ = 10.7 µM).

1787 | Fasudil, Monohydrochloride DataSheet

Alternate Name/Synonyms: 1-(5-Isoquinolinesulfonyl)homopiperazine, Monohydrochloride Salt; HA-1077, Monohydrochloride; AT-877

Appearance: White to off-white solid

Formulation: Water (175 mg/ml) or DMSO (10 mg/ml)

CAS Number: 105628-07-7

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₄H₁₇N₃O₂S•HCl

Molecular Weight: 327.83

Cell-Permeable?: Yes

Purity: ≥99% by HPLC

Solubilities: Water (175 mg/ml) or DMSO (10 mg/ml)

Handling: Protect from air and moisture

Country of Origin: USA

Tag Line: A Rho kinase (ROCK) inhibitor

MDL Number: MFCD00943198

PubChem CID: 163751

SMILES: C1CNCCN(C1)S(=O)(=O)C2=CC=CC3=C2C=CN=C3.Cl

InChi: InChI=1S/C14H17N3O2S.ClH/c18-20(19,17-9-2-6-15-8-10-17)14-4-1-3-12-11-16-7-5-13(12)14;/h1,3-5,7,11,15H,2,6,8-10H2;1H

InChi Key: LFVPBERIVUNMGV-UHFFFAOYSA-N