FBLN5 Antibody (C-term) [APR04273G]

FBLN5 Antibody (C-term) [APR04273G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This FBLN5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 393-421 amino acids from the C-terminal region of human FBLN5.

Cellular Localisation: Secreted. Secreted, extracellular space, extracellular matrix. Note=co-localizes with ELN in elastic fibers.

Molecular Weight: 50180

Clone: Polyclonal

Gene Name: FBLN5

Gene ID: 10516

Function: Essential for elastic fiber formation, is involved in the assembly of continuous elastin (ELN) polymer and promotes the interaction of microfibrils and ELN (PubMed:18185537) . Stabilizes and organizes elastic fibers in the skin, lung and vasculature (By similarity) . Promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. Vascular ligand for integrin receptors which may play a role in vascular development and remodeling (PubMed:10428823) . May act as an adapter that mediates the interaction between FBN1 and ELN (PubMed:17255108) .

Summary: Tissue Location: Expressed in skin fibroblasts (at protein level) (PubMed:17035250) . Expressed predominantly in heart, ovary, and colon but also in kidney, pancreas, testis, lung and placenta. Not detectable in brain, liver, thymus, prostate, or peripheral blood leukocytes (PubMed:10428823) .

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: Fibulin-5, FIBL-5, Developmental arteries and neural crest EGF-like protein, Dance, Urine p50 protein, UP50, FBLN5, DANCE