FBP1 Antibody (N-term) [AMM04517G]

FBP1 Antibody (N-term) [AMM04517G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This FBP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-31 amino acids from the N-terminal region of human FBP1.

Cellular Localisation: N/A

Molecular Weight: 36842

Clone: Polyclonal

Gene Name: FBP1

Gene ID: 2203

Function: Catalyzes the hydrolysis of fructose 1, 6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis. Plays a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells. Appears to modulate glycerol gluconeogenesis in liver. Important regulator of appetite and adiposity; increased expression of the protein in liver after nutrient excess increases circulating satiety hormones and reduces appetite-stimulating neuropeptides and thus seems to provide a feedback mechanism to limit weight gain.

Summary: Tissue Location: Expressed in pancreatic islets.

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: IHC-P, WB

Dilution: WB--1:1000 IHC-P--1:100~500

Synonyms: Fructose-1, 6-bisphosphatase 1, FBPase 1, D-fructose-1, 6-bisphosphate 1-phosphohydrolase 1, Liver FBPase, FBP1, FBP